AREAS OF RESEARCH
Tuberculosis
Tuberculosis is one of the deadliest infectious diseases and India has the highest number of patients suffering from tuberculosis (TB) and multi-drug resistant tuberculosis (MDR-TB). Patients have to undergo a minimum of 6 months of treatment and serious side effects using existing drug therapy. There is an urgent need for new anti-TB drugs which reduce treatment duration, work on drug resistant tuberculosis and have lesser side effects.
FNDR’s TB therapeutics program is focused on discovering small molecules that have novel chemical scaffolds, work on different targets and are synergistic with existing standard of care. Another focus area is compounds that are host-immunomodulators that can shorten the duration of treatment of TB. Please click here to see FNDR's current research programs on tuberculosis.
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Nontuberculous mycobacteria (NTM)
Nontuberculous mycobacteria (NTMs) are ubiquitous environmental pathogens that cause opportunistic progressive lung damage and respiratory failures in individuals with immunodeficiency or with structural lung diseases. There is an urgent need for drugs that work against drug resistance NTMs. ​FNDR’s NTM program is focused on discovering small molecules with novel chemical scaffolds that are synergistic with standard of care, work on drug resistant NTMs and biofilms. Please click here to see FNDR's current research programs on nontuberculous mycobacterial infections.
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Bacterial Infections
Drug resistant bacterial infections are already a major public health concern, and the scenario is expected to worsen in the future. There is an urgent need to develop new treatments. FNDR’s bacterial infections program is focused on small molecule therapeutics that have novel chemical scaffolds, novel mechanism of action and that work on CDC and WHO priority pathogens. Please click here to see FNDR's current research programs on serious bacterial infections.
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Fungal Infections
Drug resistant fungal infections are already a major public health concern, and the scenario is expected to worsen in the future. There is an urgent need to develop new treatments. FNDR’s fungal infections program is focused on small molecule therapeutics that have novel chemical scaffolds, novel mechanism of action and that work on CDC and WHO priority pathogens. Please click here to see FNDR's current research programs on serious fungal infections.​
Viral Infections
FNDR’s small molecule antiviral therapeutics program is focused on the following areas - broad spectrum antivirals that work on respiratory viruses of pandemic potential such as influenza and coronaviruses, including COVID-19 and other respiratory pathogens such as the human Respiratory Syncytial Virus (hRSV); vector transmitted viruses such as Dengue, Chikungunya, Zika, West Nile and Japanese encephalitis Virus (JEV), where antivirals are not available; and symptomatic rabies, a universally fatal neglected disease. Please click here to see FNDR's current research programs on viral infections.
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